The Synagogue, dating from the 17th century, has been located in the Jewish Ghetto since 1634.
The structure, made of exposed masonry, is equipped with five windows with Istrian stone window sills and a prayer room
a bifocal plan with Aròn (sacred wardrobe) and Bimàh (podium for reading) in wood. Of equal interest is the balustrade of the
original Bimàh carved wood with scrolls covered with gold depicting plant motifs.
The Ghetto, established in 1633 following the first papal act of Pope Urban VIII, was considered an autonomous city with its own religious organization, administrative and judicial and was a special compulsory residence for the Jews of Senigallia for two centuries until the Unification of Italy. The Ghetto in times of maximum crowding came to contain up to a thousand people.